Glyn-Jones S, Palmer AJ, Agricola R, Value AJ, Vincent TL, Weinans H, Carr AJ. Osteoarthritis. Lancet. 2015;386:376–87.
Kloppenburg M, Berenbaum F. Osteoarthritis yr in evaluation 2019: epidemiology and remedy. Osteoarthritis Cartilage. 2020;28:242–8.
Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a illness of the joint as an organ. Arthritis Rheum. 2012;64:1697–707.
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, et al. The worldwide burden of hip and knee osteoarthritis: estimates from the worldwide burden of illness 2010 examine. Ann Rheum Dis. 2014;73:1323–30.
Abramson SB, Attur M, Yazici Y. Prospects for illness modification in osteoarthritis. Nat Clin Pract Rheumatol. 2006;2:304–12.
Zhao X, Zhang L, Wang J, Zhang M, Track Z, Ni B, You Y. Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by built-in bioinformatics evaluation. J Transl Med. 2021;19:35.
Xia MD, Yu RR, Chen DM. Identification of hub biomarkers and Immune-Associated pathways taking part within the development of antineutrophil cytoplasmic Antibody-Related glomerulonephritis. Entrance Immunol. 2021;12:809325.
Zhou J, Huang J, Li Z, Track Q, Yang Z, Wang L, Meng Q. Identification of aging-related biomarkers and immune infiltration traits in osteoarthritis primarily based on bioinformatics evaluation and machine studying. Entrance Immunol. 2023;14:1168780.
Langfelder P, Horvath S. WGCNA: an R package deal for weighted correlation community evaluation. BMC Bioinformatics. 2008;9:559.
Katz JN, Arant KR, Loeser RF. Prognosis and remedy of hip and knee osteoarthritis: A evaluation. JAMA. 2021;325:568–78.
Zhou Okay, Yang C, Shi Okay, Liu Y, Hu D, He X, Yang Y, Chu B, Peng J, Zhou Z, Qian Z. Activated macrophage membrane-coated nanoparticles relieve osteoarthritis-induced synovitis and joint harm. Biomaterials. 2023;295:122036.
Xiao P, Han X, Huang Y, Yang J, Chen L, Cai Z, Hu N, Cui W, Huang W. Reprogramming macrophages by way of immune cell mobilized hydrogel microspheres for osteoarthritis remedies. Bioact Mater. 2024;32:242–59.
Li G, Liu S, Chen Y, Zhao J, Xu H, Weng J, Yu F, Xiong A, Udduttula A, Wang D, et al. An injectable liposome-anchored teriparatide integrated Gallic acid-grafted gelatin hydrogel for osteoarthritis remedy. Nat Commun. 2023;14:3159.
Sanati M, Amin YS. Liposome-integrated hydrogel hybrids: promising platforms for most cancers remedy and tissue regeneration. J Management Launch. 2024;368:703–27.
Watanabe S, Alexander M, Misharin AV, Budinger G. The function of macrophages within the decision of irritation. J Clin Make investments. 2019;129:2619–28.
Zhang H, Cai D, Bai X. Macrophages regulate the development of osteoarthritis. Osteoarthritis Cartilage. 2020;28:555–61.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, et al. The AMPK-Associated kinases SIK1 and SIK3 mediate key Tumor-Suppressive results of LKB1 in NSCLC. Most cancers Discov. 2019;9:1606–27.
Zhou F, Mei J, Han X, Li H, Yang S, Wang M, Chu L, Qiao H, Tang T. Kinsenoside attenuates osteoarthritis by repolarizing macrophages by inactivating NF-kappaB/MAPK signaling and defending chondrocytes. Acta Pharm Sin B. 2019;9:973–85.
Ebata T, Terkawi MA, Kitahara Okay, Yokota S, Shiota J, Nishida Y, Matsumae G, Alhasan H, Hamasaki M, Hontani Okay, et al. Noncanonical pyroptosis triggered by Macrophage-Derived extracellular vesicles in chondrocytes resulting in cartilage catabolism in osteoarthritis. Arthritis Rheumatol. 2023;75:1358–69.
West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. TLR signalling augments macrophage bactericidal exercise by mitochondrial ROS. Nature. 2011;472:476–80.
Garcia-Ortiz A, Serrador JM. Nitric oxide signaling in T Cell-Mediated immunity. Tendencies Mol Med. 2018;24:412–27.
Zhu J, Thompson CB. Metabolic regulation of cell progress and proliferation. Nat Rev Mol Cell Biol. 2019;20:436–50.
Toyoda E, Maehara M, Watanabe M, Sato M. Candidates for Intra-Articular administration therapeutics and therapies of osteoarthritis. Int J Mol Sci. 2021; 22.
Hu Y, Chen X, Wang S, Jing Y, Su J. Subchondral bone microenvironment in osteoarthritis and ache. Bone Res. 2021;9:20.
Wang X, Wu Q, Zhang R, Fan Z, Li W, Mao R, Du Z, Yao X, Ma Y, Yan Y, et al. Stage-specific and location-specific cartilage calcification in osteoarthritis improvement. Ann Rheum Dis. 2023;82:393–402.
Fujii Y, Liu L, Yagasaki L, Inotsume M, Chiba T, Asahara H. Cartilage homeostasis and osteoarthritis. Int J Mol Sci. 2022; 23.
Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial irritation in osteoarthritis development. Nat Rev Rheumatol. 2022;18:258–75.
Culemann S, Gruneboom A, Nicolas-Avila JA, Weidner D, Lammle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, et al. Domestically renewing resident synovial macrophages present a protecting barrier for the joint. Nature. 2019;572:670–5.
Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, et al. Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially by R-spondin-2. Ann Rheum Dis. 2018;77:1524–34.
Darling NJ, Cohen P. Nuts and bolts of the salt-inducible kinases (SIKs). Biochem J. 2021;478:1377–97.
Zhang X, Liu J, Zuo C, Peng X, Xie J, Shu Y, Ao D, Zhang Y, Ye Q, Cai J. Function of SIK1 in tumors: rising gamers and therapeutic potentials (Evaluation). Oncol Rep. 2024; 52.
Clark Okay, MacKenzie KF, Petkevicius Okay, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012;109:16986–91.
Kim MJ, Park SK, Lee JH, Jung CY, Sung DJ, Park JH, Yoon YS, Park J, Park KG, Track DK, et al. Salt-Inducible kinase 1 terminates cAMP signaling by an evolutionarily conserved Damaging-Suggestions loop in beta-Cells. Diabetes. 2015;64:3189–202.
Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran Okay, Mendoza-Rodriguez MG, Rivera-Molina YA, Gibson M, Berglund ED, Justice NJ, Berdeaux R. Skeletal muscle salt inducible kinase 1 promotes insulin resistance in weight problems. Mol Metab. 2016;5:34–46.
Sakamoto Okay, Bultot L, Goransson O. The Salt-Inducible kinases: rising metabolic regulators. Tendencies Endocrinol Metab. 2018;29:827–40.
Lombardi MS, Gillieron C, Berkelaar M, Gabay C. Salt-inducible kinases (SIK) Inhibition reduces RANKL-induced osteoclastogenesis. PLoS ONE. 2017;12:e185426.
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. 2013;38:633–43.
Li M, Yang Y, Xiong L, Jiang P, Wang J, Li C. Metabolism, metabolites, and macrophages in most cancers. J Hematol Oncol. 2023;16:80.
O’Neill LA, Kishton RJ, Rathmell J. A information to immunometabolism for immunologists. Nat Rev Immunol. 2016;16:553–65.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, et al. Pyruvate kinase M2 regulates Hif-1alpha exercise and IL-1beta induction and is a essential determinant of the Warburg impact in LPS-activated macrophages. Cell Metab. 2015;21:65–80.
Pereira M, Chen TD, Buang N, Olona A, Ko JH, Prendecki M, Costa A, Nikitopoulou E, Tronci L, Pusey CD, et al. Acute Iron deprivation reprograms human macrophage metabolism and reduces irritation in vivo. Cell Rep. 2019;28:498–511.
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, et al. HIF-1alpha is important for myeloid cell-mediated irritation. Cell. 2003;112:645–57.
Krawczyk CM, Holowka T, Solar J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. Toll-like receptor-induced modifications in glycolytic metabolism regulate dendritic cell activation. Blood. 2010;115:4742–9.
Mills EL, Kelly B, Logan A, Costa A, Varma M, Bryant CE, Tourlomousis P, Dabritz J, Gottlieb E, Latorre I, et al. Succinate dehydrogenase helps metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell. 2016;167:457–70.
Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, et al. Itaconate hyperlinks Inhibition of succinate dehydrogenase with macrophage metabolic reworking and regulation of irritation. Cell Metab. 2016;24:158–66.
Li R, Li X, Zhao J, Meng F, Yao C, Bao E, Solar N, Chen X, Cheng W, Hua H, et al. Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation. Theranostics. 2022;12:976–98.
El KK, Stenmark KR. Contribution of metabolic reprogramming to macrophage plasticity and performance. Semin Immunol. 2015;27:267–75.
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, et al. Choline uptake and metabolism modulate macrophage IL-1beta and IL-18 manufacturing. Cell Metab. 2019;29:1350–62.
Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, et al. alpha-ketoglutarate orchestrates macrophage activation by metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985–94.
Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, et al. 2019 American faculty of rheumatology/arthritis basis guideline for the administration of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72:220–33.
Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CJ. Intra-articular remedy choices for knee osteoarthritis. Nat Rev Rheumatol. 2019;15:77–90.
Li J, Mooney DJ. Designing hydrogels for managed drug supply. Nat Rev Mater. 2016; 1.
Shah S, Dhawan V, Holm R, Nagarsenker MS, Perrie Y. Liposomes: developments and innovation within the manufacturing course of. Adv Drug Deliv Rev. 2020;154–155:102–22.
Katyal P, Hettinghouse A, Meleties M, Hasan S, Chen C, Cui M, Solar G, Menon R, Lin B, Regatte R, et al. Injectable Recombinant block polymer gel for sustained supply of therapeutic protein in publish traumatic osteoarthritis. Biomaterials. 2022;281:121370.
Wan J, He Z, Peng R, Wu X, Zhu Z, Cui J, Hao X, Chen A, Zhang J, Cheng P. Injectable Photocrosslinking spherical hydrogel-encapsulated concentrating on peptide-modified engineered exosomes for osteoarthritis remedy. J Nanobiotechnol. 2023;21:284.
Wu H, Wang J, Lin Y, He W, Hou J, Deng M, Chen Y, Liu Q, Lu A, Cui Z, et al. Injectable Ozone-Wealthy nanocomposite hydrogel loaded with D-Mannose for Anti-Inflammatory and cartilage safety in osteoarthritis remedy. Small. 2024;20:e2309597.
Lin Y, Wu H, Wang J, He W, Hou J, Martin VT, Zhu C, Chen Y, Zhong J, Yu B et al. Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Method Alleviate Age-Associated Osteoarthritis. Acs Nano 2025.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, et al. Zwitterion-Lubricated hydrogel microspheres encapsulated with Metformin ameliorate Age-Related osteoarthritis. Adv Sci (Weinh). 2024;11:e2402477.
