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A nanovaccine concentrating on most cancers stem cells and bulk most cancers cells for postoperative most cancers immunotherapy


  • Hiller, J. G. et al. Perioperative occasions affect most cancers recurrence threat after surgical procedure. Nat. Rev. Clin. Oncol. 15, 205–218 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Reya, T. et al. Stem cells, most cancers, and most cancers stem cells. Nature 414, 105–111 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Barbato, L. et al. Most cancers stem cells and concentrating on methods. Cells 8, 926 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Batlle, E. & Clevers, H. Most cancers stem cells revisited. Nat. Med. 23, 1124–1134 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Prager, B. C. et al. Most cancers stem cells: the architects of the tumor ecosystem. Cell Stem Cell 24, 41–53 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chu, X. et al. Most cancers stem cells: advances in information and implications for most cancers remedy. Sign Transduct. Goal Ther. 9, 170 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gilboa, E. The promise of most cancers vaccines. Nat. Rev. Most cancers 4, 401–411 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Blass, E. & Ott, P. A. Advances within the improvement of customized neoantigen-based therapeutic most cancers vaccines. Nat. Rev. Clin. Oncol. 18, 215–229 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ruiu, R. et al. Most cancers stem cell immunology and immunotherapy: harnessing the immune system in opposition to most cancers’s supply. Prog. Mol. Biol. Transl. Sci. 164, 119–188 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ning, N. et al. Most cancers stem cell vaccination confers important antitumor immunity. Most cancers Res. 72, 1853–1864 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu, Y. et al. Therapeutic efficacy of most cancers stem cell vaccines within the adjuvant setting. Most cancers Res. 76, 4661–4672 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Klein, O. et al. Melanoma vaccines: developments over the previous 10 years. Professional Rev. Vaccines 10, 853–873 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Quaglino, E., Conti, L. & Cavallo, F. Breast most cancers stem cell antigens as targets for immunotherapy. Semin. Immunol. 47, 101386 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hassani, N. A. et al. Most cancers immunotherapy by way of concentrating on most cancers stem cells utilizing vaccine nanodiscs. Nano Lett. 20, 7783–7792 (2020).

    Article 

    Google Scholar
     

  • Ginestier, C. et al. ALDH1 is a marker of regular and malignant human mammary stem cells and a predictor of poor scientific end result. Cell Stem Cell 1, 555–567 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Silva, I. A. et al. Aldehyde dehydrogenase together with CD133 defines angiogenic ovarian most cancers stem cells that portend poor affected person survival. Most cancers Res. 71, 3991–4001 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, Q. et al. Tamoxifen enhances stemness and promotes metastasis of ERα36+ breast most cancers by upregulating ALDH1A1 in most cancers cells. Cell Res. 28, 336–358 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu, C. et al. ALDH1A1 exercise in tumor-initiating cells remodels myeloid-derived suppressor cells to advertise breast most cancers development. Most cancers Res. 81, 5919–5934 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lizee, G. et al. Management of dendritic cell cross-presentation by the most important histocompatibility advanced class I cytoplasmic area. Nat. Immunol. 4, 1065–1073 (2003).

  • Samie, M. & Cresswell, P. The transcription issue TFEB acts as a molecular change that regulates exogenous antigen-presentation pathways. Nat. Immunol. 16, 729–736 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han, D. et al. Anti-tumour immunity managed by means of mRNA m6A methylation and YTHDF1 in dendritic cells. Nature 566, 270–274 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Min, L. H. Cationic lipids-mediated dual-targeting of each dendritic cells and tumor cells for potent most cancers immunotherapy. Adv. Funct. Mater. 33, 2306752 (2023).

    Article 

    Google Scholar
     

  • Hu, M. et al. Immunogenic hybrid nanovesicles of liposomes and tumor-derived nanovesicles for most cancers immunochemotherapy. ACS Nano 15, 3123–3138 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gabrilovich, D. I., Ostrand, R. S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253–268 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Engblom, C., Pfirschke, C. & Pittet, M. J. The function of myeloid cells in most cancers therapies. Nat. Rev. Most cancers 16, 447–462 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xiao, Z., Todd, L. & Huang, L. Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in stable tumors. Nat. Commun. 14, 510 (2023).

    Article 

    Google Scholar
     

  • Lakins, M. A., Ghorani, E. & Munir, H. Most cancers-associated fibroblasts induce antigen-specific deletion of CD8+ T cells to guard tumour cells. Nat. Commun. 9, 948 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hong, J. et al. T‐cell‐derived nanovesicles for most cancers immunotherapy. Adv. Mater. 33, 2101110 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Trevaskis, N. L., Kaminskas, L. M. & Porter, C. J. From sewer to saviour—concentrating on the lymphatic system to advertise drug publicity and exercise. Nat. Rev. Drug. Discov. 14, 781–803 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen, L. et al. Bacterial cytoplasmic membranes synergistically improve the antitumor exercise of autologous most cancers vaccines. Sci. Transl. Med. 13, 601 (2021).

    Article 

    Google Scholar
     

  • von Andrian, U. H. & Mempel, T. R. Homing and mobile site visitors in lymph nodes. Nat. Rev. Immunol. 3, 867–878 (2003).

    Article 

    Google Scholar
     

  • Clatworthy, M. R. et al. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nat. Med. 20, 1458–1463 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin, W. et al. Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors by way of selling MHC-I degradation. Nat. Commun. 14, 265 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • You, Q. et al. m6A reader YTHDF1-targeting engineered small extracellular vesicles for gastric most cancers remedy by way of epigenetic and immune regulation. Adv. Mater. 35, e2204910 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Cui, C. et al. A lysosome-targeted DNA nanodevice selectively targets macrophages to attenuate tumours. Nat. Nanotechnol. 16, 1394–1402 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zehner, M. et al. The translocon protein Sec61 mediates antigen transport from endosomes within the cytosol for cross-presentation to CD8+ T cells. Immunity 42, 850–863 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • McClements, L. et al. Concentrating on treatment-resistant breast most cancers stem cells with FKBPL and its peptide by-product, AD-01, by way of the CD44 pathway. Clin. Most cancers Res. 19, 3881–3893 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Shen, S. et al. A nanotherapeutic technique to beat chemotherapeutic resistance of most cancers stem-like cells. Nat. Nanotechnol. 16, 104–113 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Dieter, S. M. et al. Distinct kinds of tumor-initiating cells kind human colon most cancers tumors and metastases. Cell Stem Cell 9, 357–365 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang, W. C. et al. Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to advertise non-small cell lung most cancers development. Nat. Commun. 7, 11702 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nguyen, L. N. M. et al. The exit of nanoparticles from stable tumours. Nat. Mater. 22, 1261–1272 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fu, A. et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast most cancers. Cell 185, 1356–1372 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, Okay. Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and protected most cancers immunotherapy. Nat. Commun. 14, 6748 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhai, Y. et al. T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for most cancers immunotherapy. Nat. Nanotechnol. 16, 1271–1280 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Krishnan, N. et al. A modular method to enhancing cell membrane-coated nanoparticle performance utilizing genetic engineering. Nat. Nanotechnol. 19, 345–353 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Elsadek, B. & Kratz, F. Influence of albumin on drug delivery-new functions on the horizon. J. Management. Launch 157, 4–28 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Track, Y. et al. Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel together with α-PD1 induces tumor remission of breast most cancers in mice. Sci. Transl. Med. 14, eabl3649 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang, S. et al. Kind 1 typical dendritic cell destiny and performance are managed by DC-SCRIPT. Sci. Immunol. 6, eabf4432 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Giampazolias, E. et al. Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and most cancers immunity. Cell 184, 4016–4031. e22 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Canton, J. et al. The receptor DNGR-1 alerts for phagosomal rupture to advertise cross-presentation of dead-cell-associated antigens. Nat. Immunol. 22, 140–153 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Roney, Okay. Bone marrow-derived dendritic cells. Strategies Mol. Biol. 1960, 57–62 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Assouvie, A., Daley-Bauer, L. P. & Rousselet, G. Rising murine bone marrow-derived macrophages. Strategies Mol. Biol. 1784, 29–33 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hui, Y. et al. Collection of DNA aptamers in opposition to DC-SIGN protein. Mol. Cell. Biochem. 306, 71–77 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ghosh, M. & Shapiro, L. H. In vitro Ag cross-presentation and in vivo Ag cross-presentation by dendritic cells within the mouse. Bio-Protocol 2, e305 (2012).

    Article 
    PubMed 

    Google Scholar
     

  • Liu, C. et al. A nanovaccine for antigen self-presentation and immunosuppression reversal as a customized most cancers immunotherapy technique. Nat. Nanotechnol. 17, 531–540 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

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